Tirzepatide vs. Semaglutide: Which One Actually Works Better?
The Core Difference Both are GLP-1 receptor agonists, but they work differently: Semaglutide (Ozempic, Wegovy) activates one receptor: the GLP-1 receptor Tirzepatide (Mounjaro, Zepbound) activates two receptors: GLP-1 + GIP (glucose-dependent insulinotropic polypeptide) The dual mechanism is why tirzepatide consistently shows greater weight loss in clinical trials — but that doesn’t automatically make it the…